Human liver cocaine carboxylesterases.

نویسندگان

  • W F Bosron
  • R A Dean
  • M R Brzezinski
  • E V Pindel
چکیده

The stimulant effects of cocaine are relatively short lived, as evidenced by the increase in heart rate that peaks at about 60 minutes after cocaine administration and declines thereafter (Farre et al. 1993). This duration of effect is largely due to the rapid hydrolysis of cocaine to two major deesterified metabolites that appear in serum and urine, benzoylecgonine and ecgonine methyl ester (figure 1). Neither of these deesterified metabolites is active as a stimulant when administered peripherally, even at high doses (Spealman et al. 1989; Misra et al. 1975). The rapid distribution half-life of cocaine from an intravenous (IV) dose is about 10 minutes and the elimination half-life of cocaine is 50 to 80 minutes (Jeffcoat et al. 1989). Hence, the duration of the stimulant action of cocaine is limited by its rate of hydrolysis to inactive metabolites.

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عنوان ژورنال:
  • NIDA research monograph

دوره 173  شماره 

صفحات  -

تاریخ انتشار 1997